Consistently evaluate patients, particularly when initiating and titrating dose and when given concomitantly with other drugs that depress respiration; alternatively, consider use of non-opioid analgesics in these patientsMonitor Closely (2)efavirenz will lower the level or effect of fentanyl by affecting hepatic/intestinal enzyme CYP3A4 metabolism
Watch Intently (one)oxcarbazepine will minimize the level or effect of fentanyl by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Observe Intently. Coadministration of fentanyl with CYP3A4 inducers could lead on to a decrease in fentanyl plasma concentrations, not enough efficacy or, possibly, enhancement of a withdrawal synd
Reserve concomitant prescribing of such drugs in patients for whom other treatment options are insufficient. Limit dosages and durations for the minimum necessary. Keep an eye on intently for signs of respiratory depression and sedation.pentazocine decreases effects of fentanyl by pharmacodynamic antagonism. Stay clear of or Use Alternate Drug. Coa
Hoehe M, 1988. Influence from the menstrual cycle on neuroendocrine and behavioral responses to an opiate agonist in humans: preliminary results. PsychoneuroendocrinologyLong term studies using potentially far more sensitive measures, like a drug versus drug alternative course of action or potential assessments of demand curves for fentanyl when co
If coadministration of CYP3A4 inhibitors with fentanyl is important, keep an eye on patients for respiratory depression and sedation at Repeated intervals and consider fentanyl dose adjustments until finally stable drug effects are realized.Use of the Internet site and any information contained herein is governed because of the Healthgrades User Se